This TED talk by Maysoon Zayid who is afflicted with cerebral palsy, is not only very funny, but so awesome on so many levels. And yes, I was teary-eyed at the end too.
Sub-titles are available in 34 different languages. You can read about the challenges faced by the translators to retain the comedic effect in 34 languages over at the TED Blog.
Lenny Says 